We would not recommend directly running the activity in the higher environment/production. Given you have already made the change in the lower environment and tested, it would be better to move the data instance you mentioned to the higher environment. One note of caution would be to confirm there is no other configuration change difference in that particular settings data instance between higher and lower environment. For example there are other setting like batch sizes etc which could have been directly modified in higher environment. Please compare the data instances XML to make sure there is no obvious differences between those.