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Standard values in CSS helper classes
Is there somewhere which defines what a "standard" value is for padding or margin used in the CSS helper classes?
For example, the help file says:
- The margin-r-2x helper class applies twice the standard margin to the right side of an item.

Yes this is correct - I do not recommend to override the whole file but instead create a new helper class CSS file attached to your skin that overrides the margin-1x, margin-2x classes
On top the helper classes, you also need to override the different dynamic layout formats if you use UI-kit. For example, the inline grid double layout in pyEndUser in UI-Kit uses 7px and 14px - you would need to change them to use 8px and 16px.